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Associate Director, Translational Medicine

Company: Deciphera Pharmaceuticals
Location: Lawrence
Posted on: November 23, 2021

Job Description:

Company Description

Deciphera is a biopharmaceutical company focused on discovering, developing and commercializing important new medicines to improve the lives of people with cancer. We are leveraging our proprietary switch-control kinase inhibitor platform and deep expertise in kinase biology to develop a broad portfolio of innovative medicines.

In addition to advancing multiple product candidates from our platform in clinical studies, QINLOCK - is Deciphera's FDA-approved switch-control kinase inhibitor for the treatment of fourth-line gastrointestinal stromal tumor (GIST). QINLOCK is also approved for fourth-line GIST in Australia, Canada, China, and Hong Kong.

Deciphera (NASDAQ: DCPH) is a publicly traded company headquartered in Waltham, Massachusetts. Our state-of-the-art research facility is located in Lawrence, Kansas.

We offer an outstanding culture and opportunity for personal and professional growth based on our "PATHS" Core Values:
Patients - places the importance of improving the lives of patients and their caregivers at the forefront of every day's work.
Accountability - for our performance and the way we work with coworkers and other stakeholders.
Transparency - in our intent and actions to both internal and external stakeholders.
Honesty and Integrity - fosters trust and strives to deliver on our and the company's promises.
Stewardship - values and uses wisely the resources and investments provided to the company.

Job Description

We are seeking an experienced, highly motivated, and technically excellent laboratory- based Associate Director, Translational Medicine with extensive experience in biomarker discovery and assay development. This person should understand clinical development and have experience developing clinically relevant biomarkers. The successful candidate will work closely with our Nonclinical Research Team and our Translational Medicine Team to develop a clinical biomarker strategy for development candidates. This person will lead a small team of internal laboratory scientists to identify biomarkers that may provide insight into pharmacodynamic effects, mechanism of action, treatment efficacy and patient selection. You will be a mentor and build strong and supportive relationships with direct reports. Overall, the ideal candidate should be focused and driven to effectively execute on team goals by managing the day-to-day activities of the Translational Medicine laboratory, spend hands-on time in the laboratory as well as managing external CRO activities.

This position will be located in our state of the art research facility in Lawrence, KS and will report to the Senior Director, Translational Medicine located in the Waltham, MA office.

Key Responsibilities
Work with cross-functional teams and Translational Medicine Team to identify biomarker needs and build a strategy for delivering robust clinical biomarker assays to enable science-driven internal decisions and assist in program progression
Collaborate with Nonclinical Research Team to address Translational Medicine questions through biomarker-driven preclinical in vivo studies
Oversee the design, development and validation of quality biomarkers to help assess mechanism of action, target engagement, proof of biologic activity and response prediction
Represent Translational Medicine in cross-functional teams and prepare and present relevant updates
Continue the build-out of new laboratory with ability to lead a technical team across multiple assay platforms
Proactively evaluate potential utility of new technologies
Provide supportive leadership and broad-based technical guidance to direct reports
Manage projects with CRO's and provide scientific guidance during assay development and assay transfers
Prepare, review and deliver high quality scientific presentations for internal/external use
Commitment to help the team achieve deliverables and meet aggressive timelines
Hands-on contribution is expected in the laboratory
Manage a small team of scientists

PhD in Cancer Biology, Molecular Biology, Biochemistry or related field
5-10 years of relevant experience in pharmaceutical or biotechnology industry with experience in Translational Science strongly preferred
Strong scientific knowledge with experience in biomarker identification and assay development is ideal
Broad technical expertise is ideal including standard molecular biology and immunoassay methods. Experience with immunohistochemistry, flow cytometry, ELISA and qRT-PCR is a plus
Strong interpersonal skills and ability to build collaborative relationships in a cross-functional environment is a must
Hands on experience in the development and qualification of biomarker assays in the preclinical and clinical setting is a plus
Strong leadership and strategic scientific thinking skills
Expertise in cutting edge assay technologies and proven assay troubleshooting skills
Prior management experience in a laboratory setting

Additional Information


Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements and to learn more about how we can increase diversity in our candidate pool, we invite you to voluntarily provide demographic information in a confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. Our commitment to increasing diversity in our candidate pool does not affect our commitment to equal employment opportunity, including our ongoing commitment to make all hiring and other employment decisions solely on a nondiscriminatory basis.

Keywords: Deciphera Pharmaceuticals, Lawrence , Associate Director, Translational Medicine, Executive , Lawrence, Kansas

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